diff --git a/gnu/packages/jemalloc.scm b/gnu/packages/jemalloc.scm
index 354f07a838..c8e355ccb3 100644
--- a/gnu/packages/jemalloc.scm
+++ b/gnu/packages/jemalloc.scm
@@ -3,6 +3,7 @@
 ;;; Copyright © 2017, 2020, 2021 Efraim Flashner <efraim@flashner.co.il>
 ;;; Copyright © 2017 Eric Bavier <bavier@member.fsf.org>
 ;;; Copyright © 2021 Ryan Sundberg <ryan@arctype.co>
+;;; Copyright © 2022 Marius Bakke <marius@gnu.org>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -25,56 +26,16 @@
   #:use-module (ice-9 match)
   #:use-module ((guix licenses) #:select (bsd-2))
   #:use-module (guix packages)
+  #:use-module (guix gexp)
   #:use-module (guix download)
   #:use-module (guix utils)
   #:use-module (gnu packages)
   #:use-module (gnu packages perl)
   #:use-module (guix build-system gnu))
 
-(define-public jemalloc-4.5.0
-  (package
-    (name "jemalloc")
-    (version "4.5.0")
-    (source (origin
-              (method url-fetch)
-              (uri (string-append
-                    "https://github.com/jemalloc/jemalloc/releases/download/"
-                    version "/jemalloc-" version ".tar.bz2"))
-              (sha256
-               (base32
-                "10373xhpc10pgmai9fkc1z0rs029qlcb3c0qfnvkbwdlcibdh2cl"))))
-    (build-system gnu-build-system)
-    (arguments
-     `(#:phases
-       (modify-phases %standard-phases
-         (add-after 'unpack 'delete-thp-test
-           ;; This test does not check if transparent huge pages are supported
-           ;; on the system before running the test.
-           (lambda _
-             (substitute* "Makefile.in"
-               (("\\$\\(srcroot\\)test/unit/pages.c \\\\") "\\"))
-             #t)))
-       #:configure-flags
-       '(,@(match (%current-system)
-             ((or "i686-linux" "x86_64-linux")
-              '())
-             ("powerpc-linux"
-              (list "--disable-thp" "CPPFLAGS=-maltivec"))
-             (_
-              (list "--disable-thp"))))))
-    ;; Install the scripts to a separate output to avoid referencing Perl and
-    ;; Bash in the default output, saving ~75 MiB on the closure.
-    (outputs '("out" "bin"))
-    (home-page "http://jemalloc.net/")
-    (synopsis "General-purpose scalable concurrent malloc implementation")
-    (description
-     "This library providing a malloc(3) implementation that emphasizes
-fragmentation avoidance and scalable concurrency support.")
-    (license bsd-2)))
-
 (define-public jemalloc
   (package
-    (inherit jemalloc-4.5.0)
+    (name "jemalloc")
     (version "5.3.0")
     (source (origin
               (method url-fetch)
@@ -84,11 +45,34 @@ fragmentation avoidance and scalable concurrency support.")
               (sha256
                (base32
                 "1apyxjd1ixy4g8xkr61p0ny8jiz8vyv1j0k4nxqkxpqrf4g2vf1d"))))
+    (build-system gnu-build-system)
     (arguments
-      (substitute-keyword-arguments (package-arguments jemalloc-4.5.0)
-        ;; Disable the thread local storage model in jemalloc 5 to prevent
-        ;; shared libraries linked to libjemalloc from crashing on dlopen()
-        ;; https://github.com/jemalloc/jemalloc/issues/937
-        ((#:configure-flags base-configure-flags '())
-         `(cons "--disable-initial-exec-tls" ,base-configure-flags))))
-    (inputs (list perl))))
+     (list
+      #:phases
+      #~(modify-phases %standard-phases
+          (add-after 'unpack 'delete-thp-test
+            ;; This test does not check if transparent huge pages are supported
+            ;; on the system before running the test.
+            (lambda _
+              (substitute* "Makefile.in"
+                (("\\$\\(srcroot\\)test/unit/pages.c \\\\") "\\")))))
+      #:configure-flags
+      ;; Disable the thread local storage model in jemalloc 5 to prevent
+      ;; shared libraries linked to libjemalloc from crashing on dlopen()
+      ;; https://github.com/jemalloc/jemalloc/issues/937
+      #~'("--disable-initial-exec-tls"
+          #$@(match (%current-system)
+               ("powerpc-linux"
+                (list "CPPFLAGS=-maltivec"))
+               (_
+                '())))))
+    (inputs (list perl))
+    ;; Install the scripts to a separate output to avoid referencing Perl and
+    ;; Bash in the default output, saving ~75 MiB on the closure.
+    (outputs '("out" "bin"))
+    (home-page "http://jemalloc.net/")
+    (synopsis "General-purpose scalable concurrent malloc implementation")
+    (description
+     "This library providing a malloc(3) implementation that emphasizes
+fragmentation avoidance and scalable concurrency support.")
+    (license bsd-2)))