diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index 794c1cc1b6..4650e5795c 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -7690,14 +7690,14 @@ adapted from transcriptomics.")
 (define-public r-dirichletmultinomial
   (package
     (name "r-dirichletmultinomial")
-    (version "1.44.0")
+    (version "1.46.0")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "DirichletMultinomial" version))
        (sha256
         (base32
-         "1rvic3acrf4qdag423f8xa6bnqrqr31vj7k4l7a5kzf1fjm359wy"))))
+         "0djd84vnf4skjr6m25ykqrvwa37lgs5r5aw9md81ykaqmi40szqb"))))
     (properties
      `((upstream-name . "DirichletMultinomial")))
     (build-system r-build-system)