diff --git a/gnu/packages/gnome-xyz.scm b/gnu/packages/gnome-xyz.scm
index 6ba9656cdd..087dd97f7d 100644
--- a/gnu/packages/gnome-xyz.scm
+++ b/gnu/packages/gnome-xyz.scm
@@ -437,7 +437,6 @@ faster window switching.")
        ("nautilus" ,nautilus)
        ("openssh" ,openssh)
        ("openssl" ,openssl)
-       ("python-nautilus" ,python-nautilus)
        ("python-pygobject" ,python-pygobject)
        ("upower" ,upower)))
     (native-inputs
diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index b2c6492cce..10d2f08705 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -16991,39 +16991,6 @@ A GraphQL schema describes your data model, and provides a GraphQL server
 with an associated set of resolve methods that know how to fetch data.")
     (license license:expat)))
 
-(define-public python-nautilus
-  (package
-    (name "python-nautilus")
-    (version "0.4.9")
-    (source
-      (origin
-        (method url-fetch)
-        (uri (pypi-uri "nautilus" version))
-        (sha256
-         (base32
-          "01hwzjc1zshk4vvxrcghm398fpy4jls66dyz06g07mrwqif8878p"))))
-    (build-system python-build-system)
-    (arguments `(#:tests? #f)) ; fails to import test modules
-    (propagated-inputs
-     `(("python-bcrypt" ,python-bcrypt)
-       ("python-click" ,python-click)
-       ("python-consul" ,python-consul)
-       ("python-graphene" ,python-graphene)
-       ("python-jinja2" ,python-jinja2)
-       ("python-peewee" ,python-peewee)
-       ("python-pika" ,python-pika)
-       ("python-tornado" ,python-tornado)
-       ("python-wtforms" ,python-wtforms)))
-    (native-inputs
-     `(("python-nose2" ,python-nose2)))
-    (home-page "https://github.com/AlecAivazis/nautilus")
-    (synopsis "Library for creating microservice applications")
-    (description
-     "Nautilus is a framework for flux based microservices that looks to
-provide extendible implementations of common aspects of a cloud so that you can
-focus on building massively scalable web applications.")
-    (license license:expat)))
-
 (define-public python-random2
   (package
     (name "python-random2")
diff --git a/gnu/packages/sync.scm b/gnu/packages/sync.scm
index ad264a0fe3..946b64b452 100644
--- a/gnu/packages/sync.scm
+++ b/gnu/packages/sync.scm
@@ -190,7 +190,6 @@
        ("libcloudproviders" ,libcloudproviders)
        ("libzip" ,libzip)
        ("openssl" ,openssl)
-       ("python-nautilus" ,python-nautilus)
        ("qtbase" ,qtbase-5)
        ("qtdeclarative" ,qtdeclarative)
        ("qtgraphicaleffects" ,qtgraphicaleffects)
diff --git a/gnu/packages/syncthing.scm b/gnu/packages/syncthing.scm
index 4deb60bee2..8880801adb 100644
--- a/gnu/packages/syncthing.scm
+++ b/gnu/packages/syncthing.scm
@@ -191,7 +191,6 @@ Protocol.")
          ("python-dateutil" ,python-dateutil)
          ("python-pycairo" ,python-pycairo)
          ("python-pygobject" ,python-pygobject)
-         ("python-nautilus" ,python-nautilus)
          ("psmisc" ,psmisc)
          ("syncthing" ,syncthing)))
       ;; (native-inputs