diff --git a/gnu/packages/patches/xpra-4.2-install_libs.patch b/gnu/packages/patches/xpra-4.2-install_libs.patch
index 92193df34a..65d489a3b8 100644
--- a/gnu/packages/patches/xpra-4.2-install_libs.patch
+++ b/gnu/packages/patches/xpra-4.2-install_libs.patch
@@ -1,22 +1,18 @@
 This workaround for Gentoo interferes with our use of --no-compile during
 the 'install stage.
 
---- a/setup.py	1970-01-01 01:00:01.000000000 +0100
-+++ b/setup.py	2022-01-06 14:08:46.710437071 +0100
-@@ -561,12 +561,6 @@
-                  % (cython_version, min_version))
+--- a/setup.py	2022-01-04 10:10:05.039825000 +0100
++++ b/setup.py	2022-01-06 15:10:31.952656039 +0100
+@@ -589,8 +589,6 @@
+         })
  
- def cython_add(extension, min_version="0.20"):
--    #gentoo does weird things, calls --no-compile with build *and* install
--    #then expects to find the cython modules!? ie:
--    #python2.7 setup.py build -b build-2.7 install --no-compile \
--    #    --root=/var/tmp/portage/x11-wm/xpra-0.7.0/temp/images/2.7
+ def add_cython_ext(*args, **kwargs):
 -    if "--no-compile" in sys.argv and not ("build" in sys.argv and "install" in sys.argv):
 -        return
      assert cython_ENABLED, "cython compilation is disabled"
-     cython_version_check(min_version)
-     from Cython.Distutils import build_ext
-@@ -1691,14 +1685,6 @@
+     if cython_tracing_ENABLED:
+         kwargs["define_macros"] = [
+@@ -1703,14 +1701,6 @@
              if uinput_ENABLED:
                  add_data_files("lib/udev/rules.d/", ["fs/lib/udev/rules.d/71-xpra-virtual-pointer.rules"])
  
diff --git a/gnu/packages/xorg.scm b/gnu/packages/xorg.scm
index 79d9be9420..e794a422c7 100644
--- a/gnu/packages/xorg.scm
+++ b/gnu/packages/xorg.scm
@@ -6315,14 +6315,14 @@ basic eye-candy effects.")
 (define-public xpra
   (package
     (name "xpra")
-    (version "4.2.2")
+    (version "4.3.1")
     (source
      (origin
        (method url-fetch)
        (uri (string-append "https://www.xpra.org/src/xpra-"
-                           version ".tar.gz"))
+                           version ".tar.xz"))
        (sha256
-        (base32 "0nky9j07zq8d5ifx568dima7a0jgs8kwhcqbg8p6gsxlgq5zdw96"))
+        (base32 "1adp790v9lq3v9pnkyf4skv69n2pd7fjqikzw145swhq9aginh5z"))
        (patches (search-patches "xpra-4.2-systemd-run.patch"
                                 "xpra-4.2-install_libs.patch"))))
     (build-system python-build-system)
@@ -6340,6 +6340,7 @@ basic eye-candy effects.")
               ("libxcomposite" ,libxcomposite)
               ("libxdamage" ,libxdamage)
               ("libxext" ,libxext)
+              ("libxres" ,libxres)
               ("gtk+" ,gtk+)
               ("python-pycairo" ,python-pycairo)
               ("python-pygobject" ,python-pygobject)