diff --git a/gnu/packages/wine.scm b/gnu/packages/wine.scm
index 72700ef3df..517b9f236e 100644
--- a/gnu/packages/wine.scm
+++ b/gnu/packages/wine.scm
@@ -147,3 +147,23 @@ integrate Windows applications into your desktop.")
     ;; It really only supports IA32, but building on x86_64 will have the same
     ;; effect as building on i686 anyway.
     (supported-systems '("i686-linux" "x86_64-linux"))))
+
+(define-public wine64
+  (package
+    (inherit wine)
+    (name "wine64")
+    (arguments
+     `(#:configure-flags
+       (list "--enable-win64"
+             (string-append "LDFLAGS=-Wl,-rpath=" %output "/lib64"))
+       ,@(strip-keyword-arguments '(#:configure-flags #:system)
+                                  (package-arguments wine))))
+    (synopsis "Implementation of the Windows API (64-bit version)")
+    (description
+     "Wine (originally an acronym for \"Wine Is Not an Emulator\") is a
+compatibility layer capable of running Windows applications.  Instead of
+simulating internal Windows logic like a virtual machine or emulator, Wine
+translates Windows API calls into POSIX calls on-the-fly, eliminating the
+performance and memory penalties of other methods and allowing you to cleanly
+integrate Windows applications into your desktop.  This is the 64-bit version.")
+    (supported-systems '("x86_64-linux"))))