804 lines
		
	
	
	
		
			31 KiB
		
	
	
	
		
			Scheme
		
	
	
	
	
	
			
		
		
	
	
			804 lines
		
	
	
	
		
			31 KiB
		
	
	
	
		
			Scheme
		
	
	
	
	
	
;;; GNU Guix --- Functional package management for GNU
 | 
						||
;;; Copyright © 2018 Ricardo Wurmus <rekado@elephly.net>
 | 
						||
;;; Copyright © 2018 Roel Janssen <roel@gnu.org>
 | 
						||
;;; Copyright © 2018 Tobias Geerinckx-Rice <me@tobias.gr>
 | 
						||
;;;
 | 
						||
;;; This file is part of GNU Guix.
 | 
						||
;;;
 | 
						||
;;; GNU Guix is free software; you can redistribute it and/or modify it
 | 
						||
;;; under the terms of the GNU General Public License as published by
 | 
						||
;;; the Free Software Foundation; either version 3 of the License, or (at
 | 
						||
;;; your option) any later version.
 | 
						||
;;;
 | 
						||
;;; GNU Guix is distributed in the hope that it will be useful, but
 | 
						||
;;; WITHOUT ANY WARRANTY; without even the implied warranty of
 | 
						||
;;; MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 | 
						||
;;; GNU General Public License for more details.
 | 
						||
;;;
 | 
						||
;;; You should have received a copy of the GNU General Public License
 | 
						||
;;; along with GNU Guix.  If not, see <http://www.gnu.org/licenses/>.
 | 
						||
 | 
						||
(define-module (gnu packages bioconductor)
 | 
						||
  #:use-module ((guix licenses) #:prefix license:)
 | 
						||
  #:use-module (guix packages)
 | 
						||
  #:use-module (guix download)
 | 
						||
  #:use-module (guix build-system r)
 | 
						||
  #:use-module (gnu packages)
 | 
						||
  #:use-module (gnu packages bioinformatics)
 | 
						||
  #:use-module (gnu packages cran)
 | 
						||
  #:use-module (gnu packages compression)
 | 
						||
  #:use-module (gnu packages graph)
 | 
						||
  #:use-module (gnu packages statistics)
 | 
						||
  #:use-module (gnu packages web))
 | 
						||
 | 
						||
(define-public r-bsgenome-dmelanogaster-ucsc-dm6
 | 
						||
  (package
 | 
						||
    (name "r-bsgenome-dmelanogaster-ucsc-dm6")
 | 
						||
    (version "1.4.1")
 | 
						||
    (source (origin
 | 
						||
              (method url-fetch)
 | 
						||
              ;; We cannot use bioconductor-uri here because this tarball is
 | 
						||
              ;; located under "data/annotation/" instead of "bioc/".
 | 
						||
              (uri (string-append "https://www.bioconductor.org/packages/"
 | 
						||
                                  "release/data/annotation/src/contrib/"
 | 
						||
                                  "BSgenome.Dmelanogaster.UCSC.dm6_"
 | 
						||
                                  version ".tar.gz"))
 | 
						||
              (sha256
 | 
						||
               (base32
 | 
						||
                "1bhj0rdgf7lspw4xby9y9mf7v7jxxz8001bc8vw8kf04rjsx6060"))))
 | 
						||
    (properties
 | 
						||
     `((upstream-name . "BSgenome.Dmelanogaster.UCSC.dm6")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    ;; As this package provides little more than a very large data file it
 | 
						||
    ;; doesn't make sense to build substitutes.
 | 
						||
    (arguments `(#:substitutable? #f))
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-bsgenome" ,r-bsgenome)))
 | 
						||
    (home-page
 | 
						||
     "https://www.bioconductor.org/packages/BSgenome.Dmelanogaster.UCSC.dm6/")
 | 
						||
    (synopsis "Full genome sequences for Fly")
 | 
						||
    (description
 | 
						||
     "This package provides full genome sequences for Drosophila
 | 
						||
melanogaster (Fly) as provided by UCSC (dm6) and stored in Biostrings
 | 
						||
objects.")
 | 
						||
    (license license:artistic2.0)))
 | 
						||
 | 
						||
(define-public r-bsgenome-dmelanogaster-ucsc-dm3-masked
 | 
						||
  (package
 | 
						||
    (name "r-bsgenome-dmelanogaster-ucsc-dm3-masked")
 | 
						||
    (version "1.3.99")
 | 
						||
    (source (origin
 | 
						||
              (method url-fetch)
 | 
						||
              ;; We cannot use bioconductor-uri here because this tarball is
 | 
						||
              ;; located under "data/annotation/" instead of "bioc/".
 | 
						||
              (uri (string-append "http://www.bioconductor.org/packages/"
 | 
						||
                                  "release/data/annotation/src/contrib/"
 | 
						||
                                  "BSgenome.Dmelanogaster.UCSC.dm3.masked_"
 | 
						||
                                  version ".tar.gz"))
 | 
						||
              (sha256
 | 
						||
               (base32
 | 
						||
                "1756csb09f1br9rj1l3f08qyh4hlymdbd0cfn8x3fq39dn45m5ap"))))
 | 
						||
    (properties
 | 
						||
     `((upstream-name . "BSgenome.Dmelanogaster.UCSC.dm3.masked")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-bsgenome" ,r-bsgenome)
 | 
						||
       ("r-bsgenome-dmelanogaster-ucsc-dm3"
 | 
						||
        ,r-bsgenome-dmelanogaster-ucsc-dm3)))
 | 
						||
    (home-page "https://www.bioconductor.org/packages/BSgenome.Dmelanogaster.UCSC.dm3.masked/")
 | 
						||
    (synopsis "Full masked genome sequences for Fly")
 | 
						||
    (description
 | 
						||
     "This package provides full masked genome sequences for Drosophila
 | 
						||
melanogaster (Fly) as provided by UCSC (dm3, April 2006) and stored in
 | 
						||
Biostrings objects.  The sequences are the same as in
 | 
						||
BSgenome.Dmelanogaster.UCSC.dm3, except that each of them has the 4 following
 | 
						||
masks on top: (1) the mask of assembly gaps (AGAPS mask), (2) the mask of
 | 
						||
intra-contig ambiguities (AMB mask), (3) the mask of repeats from
 | 
						||
RepeatMasker (RM mask), and (4) the mask of repeats from Tandem Repeats
 | 
						||
Finder (TRF mask).  Only the AGAPS and AMB masks are \"active\" by default.")
 | 
						||
    (license license:artistic2.0)))
 | 
						||
 | 
						||
(define-public r-bsgenome-hsapiens-ucsc-hg19-masked
 | 
						||
  (package
 | 
						||
    (name "r-bsgenome-hsapiens-ucsc-hg19-masked")
 | 
						||
    (version "1.3.99")
 | 
						||
    (source (origin
 | 
						||
              (method url-fetch)
 | 
						||
              ;; We cannot use bioconductor-uri here because this tarball is
 | 
						||
              ;; located under "data/annotation/" instead of "bioc/".
 | 
						||
              (uri (string-append "http://www.bioconductor.org/packages/"
 | 
						||
                                  "release/data/annotation/src/contrib/"
 | 
						||
                                  "BSgenome.Hsapiens.UCSC.hg19.masked_"
 | 
						||
                                  version ".tar.gz"))
 | 
						||
              (sha256
 | 
						||
               (base32
 | 
						||
                "0452pyah0kv1vsrsjbrqw4k2rm8lc2vc771dzib45gnnfz86qxrr"))))
 | 
						||
    (properties
 | 
						||
     `((upstream-name . "BSgenome.Hsapiens.UCSC.hg19.masked")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-bsgenome" ,r-bsgenome)
 | 
						||
       ("r-bsgenome-hsapiens-ucsc-hg19"
 | 
						||
        ,r-bsgenome-hsapiens-ucsc-hg19)))
 | 
						||
    (home-page "https://bioconductor.org/packages/BSgenome.Hsapiens.UCSC.hg19.masked/")
 | 
						||
    (synopsis "Full masked genome sequences for Homo sapiens")
 | 
						||
    (description
 | 
						||
     "This package provides full genome sequences for Homo sapiens (Human) as
 | 
						||
provided by UCSC (hg19, Feb. 2009) and stored in Biostrings objects.  The
 | 
						||
sequences are the same as in BSgenome.Hsapiens.UCSC.hg19, except that each of
 | 
						||
them has the 4 following masks on top: (1) the mask of assembly gaps (AGAPS
 | 
						||
mask), (2) the mask of intra-contig ambiguities (AMB mask), (3) the mask of
 | 
						||
repeats from RepeatMasker (RM mask), and (4) the mask of repeats from Tandem
 | 
						||
Repeats Finder (TRF mask).  Only the AGAPS and AMB masks are \"active\" by
 | 
						||
default.")
 | 
						||
    (license license:artistic2.0)))
 | 
						||
 | 
						||
(define-public r-bsgenome-mmusculus-ucsc-mm9-masked
 | 
						||
  (package
 | 
						||
    (name "r-bsgenome-mmusculus-ucsc-mm9-masked")
 | 
						||
    (version "1.3.99")
 | 
						||
    (source (origin
 | 
						||
              (method url-fetch)
 | 
						||
              ;; We cannot use bioconductor-uri here because this tarball is
 | 
						||
              ;; located under "data/annotation/" instead of "bioc/".
 | 
						||
              (uri (string-append "http://www.bioconductor.org/packages/"
 | 
						||
                                  "release/data/annotation/src/contrib/"
 | 
						||
                                  "BSgenome.Mmusculus.UCSC.mm9.masked_"
 | 
						||
                                  version ".tar.gz"))
 | 
						||
              (sha256
 | 
						||
               (base32
 | 
						||
                "00bpbm3havqcxr4g63zhllsbpd9q6svgihks7qp7x73nm4gvq7fn"))))
 | 
						||
    (properties
 | 
						||
     `((upstream-name . "BSgenome.Mmusculus.UCSC.mm9.masked")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-bsgenome" ,r-bsgenome)
 | 
						||
       ("r-bsgenome-mmusculus-ucsc-mm9"
 | 
						||
        ,r-bsgenome-mmusculus-ucsc-mm9)))
 | 
						||
    (home-page "http://bioconductor.org/packages/BSgenome.Mmusculus.UCSC.mm9.masked/")
 | 
						||
    (synopsis "Full masked genome sequences for Mouse")
 | 
						||
    (description
 | 
						||
     "This package provides full genome sequences for Mus musculus (Mouse) as
 | 
						||
provided by UCSC (mm9, Jul. 2007) and stored in Biostrings objects.  The
 | 
						||
sequences are the same as in BSgenome.Mmusculus.UCSC.mm9, except that each of
 | 
						||
them has the 4 following masks on top: (1) the mask of assembly gaps (AGAPS
 | 
						||
mask), (2) the mask of intra-contig ambiguities (AMB mask), (3) the mask of
 | 
						||
repeats from RepeatMasker (RM mask), and (4) the mask of repeats from Tandem
 | 
						||
Repeats Finder (TRF mask).  Only the AGAPS and AMB masks are \"active\" by
 | 
						||
default."  )
 | 
						||
    (license license:artistic2.0)))
 | 
						||
 | 
						||
(define-public r-genelendatabase
 | 
						||
  (package
 | 
						||
    (name "r-genelendatabase")
 | 
						||
    (version "1.16.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       ;; We cannot use bioconductor-uri here because this tarball is
 | 
						||
       ;; located under "data/experiment/" instead of "bioc/".
 | 
						||
       (uri (string-append "https://bioconductor.org/packages/"
 | 
						||
                           "release/data/experiment/src/contrib"
 | 
						||
                           "/geneLenDataBase_" version ".tar.gz"))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "07mmmn53kb7v14msc13dsbm8ghssbvwcrhifrk15hn37bw2p4ja5"))))
 | 
						||
    (properties
 | 
						||
     `((upstream-name . "geneLenDataBase")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-rtracklayer" ,r-rtracklayer)
 | 
						||
       ("r-genomicfeatures" ,r-genomicfeatures)))
 | 
						||
    (home-page "https://bioconductor.org/packages/geneLenDataBase/")
 | 
						||
    (synopsis "Lengths of mRNA transcripts for a number of genomes")
 | 
						||
    (description
 | 
						||
     "This package provides the lengths of mRNA transcripts for a number of
 | 
						||
genomes and gene ID formats, largely based on the UCSC table browser.")
 | 
						||
    (license license:lgpl2.0+)))
 | 
						||
 | 
						||
 | 
						||
(define-public r-hpar
 | 
						||
  (package
 | 
						||
    (name "r-hpar")
 | 
						||
    (version "1.22.2")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "hpar" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "1b72hvzasf6q739gmx6jblbzzyq22l7crrkbbfkihv3v7s94g388"))))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (home-page "https://bioconductor.org/packages/hpar/")
 | 
						||
    (synopsis "Human Protein Atlas in R")
 | 
						||
    (description "This package provides a simple interface to and data from
 | 
						||
the Human Protein Atlas project.")
 | 
						||
    (license license:artistic2.0)))
 | 
						||
 | 
						||
(define-public r-regioner
 | 
						||
  (package
 | 
						||
    (name "r-regioner")
 | 
						||
    (version "1.12.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "regioneR" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "09bzlaqdgy7wmzly3zc9y2da50d07mlixlnpaxdxpiwdk8qmhxsb"))))
 | 
						||
    (properties `((upstream-name . "regioneR")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-memoise" ,r-memoise)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-bsgenome" ,r-bsgenome)
 | 
						||
       ("r-rtracklayer" ,r-rtracklayer)
 | 
						||
       ("r-genomeinfodb" ,r-genomeinfodb)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)))
 | 
						||
    (home-page "https://bioconductor.org/packages/regioneR/")
 | 
						||
    (synopsis "Association analysis of genomic regions")
 | 
						||
    (description "This package offers a statistical framework based on
 | 
						||
customizable permutation tests to assess the association between genomic
 | 
						||
region sets and other genomic features.")
 | 
						||
    (license license:artistic2.0)))
 | 
						||
 | 
						||
(define-public r-diffbind
 | 
						||
  (package
 | 
						||
    (name "r-diffbind")
 | 
						||
    (version "2.8.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "DiffBind" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "1w1hybzd732ccg3q8zhirwfilq8sx3frv1x98zfyj3svzw98fish"))))
 | 
						||
    (properties `((upstream-name . "DiffBind")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (inputs
 | 
						||
     `(("zlib" ,zlib)))
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-amap" ,r-amap)
 | 
						||
       ("r-biocparallel" ,r-biocparallel)
 | 
						||
       ("r-deseq2" ,r-deseq2)
 | 
						||
       ("r-dplyr" ,r-dplyr)
 | 
						||
       ("r-edger" ,r-edger)
 | 
						||
       ("r-genomicalignments" ,r-genomicalignments)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-ggplot2" ,r-ggplot2)
 | 
						||
       ("r-ggrepel" ,r-ggrepel)
 | 
						||
       ("r-gplots" ,r-gplots)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-lattice" ,r-lattice)
 | 
						||
       ("r-limma" ,r-limma)
 | 
						||
       ("r-locfit" ,r-locfit)
 | 
						||
       ("r-rcolorbrewer" , r-rcolorbrewer)
 | 
						||
       ("r-rcpp" ,r-rcpp)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)
 | 
						||
       ("r-summarizedexperiment" ,r-summarizedexperiment)
 | 
						||
       ("r-systempiper" ,r-systempiper)
 | 
						||
       ("r-zlibbioc" ,r-zlibbioc)))
 | 
						||
    (home-page "http://bioconductor.org/packages/DiffBind")
 | 
						||
    (synopsis "Differential binding analysis of ChIP-Seq peak data")
 | 
						||
    (description
 | 
						||
     "This package computes differentially bound sites from multiple
 | 
						||
ChIP-seq experiments using affinity (quantitative) data.  Also enables
 | 
						||
occupancy (overlap) analysis and plotting functions.")
 | 
						||
    (license license:artistic2.0)))
 | 
						||
 | 
						||
(define-public r-ripseeker
 | 
						||
  (package
 | 
						||
    (name "r-ripseeker")
 | 
						||
    (version "1.20.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "RIPSeeker" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0y9cvzqslfxj3z9mnp47mknff0pky2g5x8x1z1s5yjcx35q89xfi"))))
 | 
						||
    (properties `((upstream-name . "RIPSeeker")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-s4vectors" ,r-s4vectors)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-summarizedexperiment" ,r-summarizedexperiment)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)
 | 
						||
       ("r-genomicalignments" ,r-genomicalignments)
 | 
						||
       ("r-rtracklayer" ,r-rtracklayer)))
 | 
						||
    (home-page "http://bioconductor.org/packages/RIPSeeker")
 | 
						||
    (synopsis
 | 
						||
     "Identifying protein-associated transcripts from RIP-seq experiments")
 | 
						||
    (description
 | 
						||
     "This package infers and discriminates RIP peaks from RIP-seq alignments
 | 
						||
using two-state HMM with negative binomial emission probability.  While
 | 
						||
RIPSeeker is specifically tailored for RIP-seq data analysis, it also provides
 | 
						||
a suite of bioinformatics tools integrated within this self-contained software
 | 
						||
package comprehensively addressing issues ranging from post-alignments
 | 
						||
processing to visualization and annotation.")
 | 
						||
    (license license:gpl2)))
 | 
						||
 | 
						||
(define-public r-multtest
 | 
						||
  (package
 | 
						||
    (name "r-multtest")
 | 
						||
    (version "2.36.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "multtest" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "11949h2kglw13x8haaj4clg4jim1mwh5n98n9zxp9mmgn01z1lp0"))))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-survival" ,r-survival)
 | 
						||
       ("r-biocgenerics" ,r-biocgenerics)
 | 
						||
       ("r-biobase" ,r-biobase)
 | 
						||
       ("r-mass" ,r-mass)))
 | 
						||
    (home-page "http://bioconductor.org/packages/multtest")
 | 
						||
    (synopsis "Resampling-based multiple hypothesis testing")
 | 
						||
    (description
 | 
						||
     "This package can do non-parametric bootstrap and permutation
 | 
						||
resampling-based multiple testing procedures (including empirical Bayes
 | 
						||
methods) for controlling the family-wise error rate (FWER), generalized
 | 
						||
family-wise error rate (gFWER), tail probability of the proportion of
 | 
						||
false positives (TPPFP), and false discovery rate (FDR).  Several choices
 | 
						||
of bootstrap-based null distribution are implemented (centered, centered
 | 
						||
and scaled, quantile-transformed).  Single-step and step-wise methods are
 | 
						||
available.  Tests based on a variety of T- and F-statistics (including
 | 
						||
T-statistics based on regression parameters from linear and survival models
 | 
						||
as well as those based on correlation parameters) are included.  When probing
 | 
						||
hypotheses with T-statistics, users may also select a potentially faster null
 | 
						||
distribution which is multivariate normal with mean zero and variance
 | 
						||
covariance matrix derived from the vector influence function.  Results are
 | 
						||
reported in terms of adjusted P-values, confidence regions and test statistic
 | 
						||
cutoffs.  The procedures are directly applicable to identifying differentially
 | 
						||
expressed genes in DNA microarray experiments.")
 | 
						||
    (license license:lgpl3)))
 | 
						||
 | 
						||
(define-public r-chippeakanno
 | 
						||
  (package
 | 
						||
    (name "r-chippeakanno")
 | 
						||
    (version "3.14.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "ChIPpeakAnno" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "1kcnc3cnmrhdk1x7q3y6zsz09pgd3xn9xy1hfbxz48cajlb18ad0"))))
 | 
						||
    (properties `((upstream-name . "ChIPpeakAnno")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-biocgenerics" ,r-biocgenerics)
 | 
						||
       ("r-biostrings" ,r-biostrings)
 | 
						||
       ("r-delayedarray" ,r-delayedarray)
 | 
						||
       ("r-go-db" ,r-go-db)
 | 
						||
       ("r-biomart" ,r-biomart)
 | 
						||
       ("r-bsgenome" ,r-bsgenome)
 | 
						||
       ("r-genomicfeatures" ,r-genomicfeatures)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-genomeinfodb" ,r-genomeinfodb)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-matrixstats" ,r-matrixstats)
 | 
						||
       ("r-annotationdbi" ,r-annotationdbi)
 | 
						||
       ("r-limma" ,r-limma)
 | 
						||
       ("r-multtest" ,r-multtest)
 | 
						||
       ("r-rbgl" ,r-rbgl)
 | 
						||
       ("r-graph" ,r-graph)
 | 
						||
       ("r-biocinstaller" ,r-biocinstaller)
 | 
						||
       ("r-regioner" ,r-regioner)
 | 
						||
       ("r-dbi" ,r-dbi)
 | 
						||
       ("r-ensembldb" ,r-ensembldb)
 | 
						||
       ("r-biobase" ,r-biobase)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)
 | 
						||
       ("r-seqinr" ,r-seqinr)
 | 
						||
       ("r-idr" ,r-idr)
 | 
						||
       ("r-genomicalignments" ,r-genomicalignments)
 | 
						||
       ("r-summarizedexperiment" ,r-summarizedexperiment)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)
 | 
						||
       ("r-venndiagram" ,r-venndiagram)))
 | 
						||
    (home-page "http://bioconductor.org/packages/ChIPpeakAnno")
 | 
						||
    (synopsis "Peaks annotation from ChIP-seq and ChIP-chip experiments")
 | 
						||
    (description
 | 
						||
     "The package includes functions to retrieve the sequences around the peak,
 | 
						||
obtain enriched Gene Ontology (GO) terms, find the nearest gene, exon, miRNA or
 | 
						||
custom features such as most conserved elements and other transcription factor
 | 
						||
binding sites supplied by users.  Starting 2.0.5, new functions have been added
 | 
						||
for finding the peaks with bi-directional promoters with summary statistics
 | 
						||
(peaksNearBDP), for summarizing the occurrence of motifs in peaks
 | 
						||
(summarizePatternInPeaks) and for adding other IDs to annotated peaks or
 | 
						||
enrichedGO (addGeneIDs).")
 | 
						||
    (license license:gpl2+)))
 | 
						||
 | 
						||
(define-public r-marray
 | 
						||
  (package
 | 
						||
    (name "r-marray")
 | 
						||
    (version "1.58.0")
 | 
						||
    (source (origin
 | 
						||
              (method url-fetch)
 | 
						||
              (uri (bioconductor-uri "marray" version))
 | 
						||
              (sha256
 | 
						||
               (base32 "0539flh3y1qy5b1bamkfwbskis765c5s33v1y9j51n33mxb9h08d"))))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-limma" ,r-limma)))
 | 
						||
    (home-page "http://bioconductor.org/packages/marray")
 | 
						||
    (synopsis "Exploratory analysis for two-color spotted microarray data")
 | 
						||
    (description "This package contains class definitions for two-color spotted
 | 
						||
microarray data.  It also includes fuctions for data input, diagnostic plots,
 | 
						||
normalization and quality checking.")
 | 
						||
    (license license:lgpl2.0+)))
 | 
						||
 | 
						||
(define-public r-cghbase
 | 
						||
  (package
 | 
						||
   (name "r-cghbase")
 | 
						||
   (version "1.40.0")
 | 
						||
   (source (origin
 | 
						||
            (method url-fetch)
 | 
						||
            (uri (bioconductor-uri "CGHbase" version))
 | 
						||
            (sha256
 | 
						||
             (base32 "1hf44vma3kgwr61kjbszvfxkava8bjqnam1mdncqvczbypb2xwaq"))))
 | 
						||
   (properties `((upstream-name . "CGHbase")))
 | 
						||
   (build-system r-build-system)
 | 
						||
   (propagated-inputs
 | 
						||
    `(("r-biobase" ,r-biobase)
 | 
						||
      ("r-marray" ,r-marray)))
 | 
						||
   (home-page "http://bioconductor.org/packages/CGHbase")
 | 
						||
   (synopsis "Base functions and classes for arrayCGH data analysis")
 | 
						||
   (description "This package contains functions and classes that are needed by
 | 
						||
the @code{arrayCGH} packages.")
 | 
						||
   (license license:gpl2+)))
 | 
						||
 | 
						||
(define-public r-cghcall
 | 
						||
  (package
 | 
						||
   (name "r-cghcall")
 | 
						||
   (version "2.42.0")
 | 
						||
   (source (origin
 | 
						||
            (method url-fetch)
 | 
						||
            (uri (bioconductor-uri "CGHcall" version))
 | 
						||
            (sha256
 | 
						||
             (base32 "0y71vfxv9x0am3xvv520yr95cb7m7y92dhdx1vkqki80jrmf12dz"))))
 | 
						||
   (properties `((upstream-name . "CGHcall")))
 | 
						||
   (build-system r-build-system)
 | 
						||
   (propagated-inputs
 | 
						||
    `(("r-biobase" ,r-biobase)
 | 
						||
      ("r-cghbase" ,r-cghbase)
 | 
						||
      ("r-impute" ,r-impute)
 | 
						||
      ("r-dnacopy" ,r-dnacopy)
 | 
						||
      ("r-snowfall" ,r-snowfall)))
 | 
						||
   (home-page "http://bioconductor.org/packages/CGHcall")
 | 
						||
   (synopsis "Base functions and classes for arrayCGH data analysis")
 | 
						||
   (description "This package contains functions and classes that are needed by
 | 
						||
@code{arrayCGH} packages.")
 | 
						||
   (license license:gpl2+)))
 | 
						||
 | 
						||
(define-public r-qdnaseq
 | 
						||
  (package
 | 
						||
    (name "r-qdnaseq")
 | 
						||
    (version "1.16.0")
 | 
						||
    (source (origin
 | 
						||
              (method url-fetch)
 | 
						||
              (uri (bioconductor-uri "QDNAseq" version))
 | 
						||
              (sha256
 | 
						||
               (base32 "1pj69mfyxwfd0d7h4kls9xq96sdc55y3rv20qpla50hw9libcwwd"))))
 | 
						||
    (properties `((upstream-name . "QDNAseq")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-biobase" ,r-biobase)
 | 
						||
       ("r-biocparallel" ,r-biocparallel)
 | 
						||
       ("r-cghbase" ,r-cghbase)
 | 
						||
       ("r-cghcall" ,r-cghcall)
 | 
						||
       ("r-dnacopy" ,r-dnacopy)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-matrixstats" ,r-matrixstats)
 | 
						||
       ("r-r-utils" ,r-r-utils)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)))
 | 
						||
    (home-page "http://bioconductor.org/packages/QDNAseq")
 | 
						||
    (synopsis "Quantitative DNA sequencing for chromosomal aberrations")
 | 
						||
    (description "The genome is divided into non-overlapping fixed-sized bins,
 | 
						||
number of sequence reads in each counted, adjusted with a simultaneous
 | 
						||
two-dimensional loess correction for sequence mappability and GC content, and
 | 
						||
filtered to remove spurious regions in the genome.  Downstream steps of
 | 
						||
segmentation and calling are also implemented via packages DNAcopy and CGHcall,
 | 
						||
respectively.")
 | 
						||
    (license license:gpl2+)))
 | 
						||
 | 
						||
(define-public r-bayseq
 | 
						||
  (package
 | 
						||
    (name "r-bayseq")
 | 
						||
    (version "2.14.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "baySeq" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0hbmm01a8libara9mbxknpk0wzarwfngnfwlmhpww91a0cmy5klg"))))
 | 
						||
    (properties `((upstream-name . "baySeq")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-abind" ,r-abind)
 | 
						||
       ("r-edger" ,r-edger)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)))
 | 
						||
    (home-page "https://bioconductor.org/packages/baySeq/")
 | 
						||
    (synopsis "Bayesian analysis of differential expression patterns in count data")
 | 
						||
    (description
 | 
						||
     "This package identifies differential expression in high-throughput count
 | 
						||
data, such as that derived from next-generation sequencing machines,
 | 
						||
calculating estimated posterior likelihoods of differential expression (or
 | 
						||
more complex hypotheses) via empirical Bayesian methods.")
 | 
						||
    (license license:gpl3)))
 | 
						||
 | 
						||
(define-public r-chipcomp
 | 
						||
  (package
 | 
						||
    (name "r-chipcomp")
 | 
						||
    (version "1.10.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "ChIPComp" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0j9nif7z33qdxf347r9wa62hhz8qs09r2p96x3hg5yz30a10ahqs"))))
 | 
						||
    (properties `((upstream-name . "ChIPComp")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-biocgenerics" ,r-biocgenerics)
 | 
						||
       ("r-bsgenome-hsapiens-ucsc-hg19" ,r-bsgenome-hsapiens-ucsc-hg19)
 | 
						||
       ("r-bsgenome-mmusculus-ucsc-mm9" ,r-bsgenome-mmusculus-ucsc-mm9)
 | 
						||
       ("r-genomeinfodb" ,r-genomeinfodb)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-limma" ,r-limma)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)
 | 
						||
       ("r-rtracklayer" ,r-rtracklayer)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)))
 | 
						||
    (home-page "https://bioconductor.org/packages/ChIPComp")
 | 
						||
    (synopsis "Quantitative comparison of multiple ChIP-seq datasets")
 | 
						||
    (description
 | 
						||
     "ChIPComp implements a statistical method for quantitative comparison of
 | 
						||
multiple ChIP-seq datasets.  It detects differentially bound sharp binding
 | 
						||
sites across multiple conditions considering matching control in ChIP-seq
 | 
						||
datasets.")
 | 
						||
    ;; Any version of the GPL.
 | 
						||
    (license license:gpl3+)))
 | 
						||
 | 
						||
(define-public r-riboprofiling
 | 
						||
  (package
 | 
						||
    (name "r-riboprofiling")
 | 
						||
    (version "1.10.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "RiboProfiling" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "04yjklqdjkim7yxyk3cyvf0mmwyxyfvw2mmfzgwaaqbiyg29sli0"))))
 | 
						||
    (properties `((upstream-name . "RiboProfiling")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-biocgenerics" ,r-biocgenerics)
 | 
						||
       ("r-biostrings" ,r-biostrings)
 | 
						||
       ("r-data-table" ,r-data-table)
 | 
						||
       ("r-genomeinfodb" ,r-genomeinfodb)
 | 
						||
       ("r-genomicalignments" ,r-genomicalignments)
 | 
						||
       ("r-genomicfeatures" ,r-genomicfeatures)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-ggbio" ,r-ggbio)
 | 
						||
       ("r-ggplot2" ,r-ggplot2)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-plyr" ,r-plyr)
 | 
						||
       ("r-reshape2" ,r-reshape2)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)
 | 
						||
       ("r-rtracklayer" ,r-rtracklayer)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)
 | 
						||
       ("r-sqldf" ,r-sqldf)))
 | 
						||
    (home-page "https://bioconductor.org/packages/RiboProfiling/")
 | 
						||
    (synopsis "Ribosome profiling data analysis")
 | 
						||
    (description "Starting with a BAM file, this package provides the
 | 
						||
necessary functions for quality assessment, read start position recalibration,
 | 
						||
the counting of genomic sequence reads on CDS, 3'UTR, and 5'UTR, and plotting
 | 
						||
of count data: pairs, log fold-change, codon frequency and coverage
 | 
						||
assessment, principal component analysis on codon coverage.")
 | 
						||
    (license license:gpl3)))
 | 
						||
 | 
						||
(define-public r-riboseqr
 | 
						||
  (package
 | 
						||
    (name "r-riboseqr")
 | 
						||
    (version "1.14.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "riboSeqR" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0xavd1cdhi8qfjn9a1hjhflyg6jq1ydvv56z12gjz572pwz2knvn"))))
 | 
						||
    (properties `((upstream-name . "riboSeqR")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-abind" ,r-abind)
 | 
						||
       ("r-bayseq" ,r-bayseq)
 | 
						||
       ("r-genomeinfodb" ,r-genomeinfodb)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)
 | 
						||
       ("r-seqlogo" ,r-seqlogo)))
 | 
						||
    (home-page "https://bioconductor.org/packages/riboSeqR/")
 | 
						||
    (synopsis "Analysis of sequencing data from ribosome profiling experiments")
 | 
						||
    (description
 | 
						||
     "This package provides plotting functions, frameshift detection and
 | 
						||
parsing of genetic sequencing data from ribosome profiling experiments.")
 | 
						||
    (license license:gpl3)))
 | 
						||
 | 
						||
(define-public r-interactionset
 | 
						||
  (package
 | 
						||
    (name "r-interactionset")
 | 
						||
    (version "1.8.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "InteractionSet" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0xngraq7ic80jr98i1wqp8bxdgidq6py60m2wfk82n1ixpcdck8n"))))
 | 
						||
    (properties
 | 
						||
     `((upstream-name . "InteractionSet")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-biocgenerics" ,r-biocgenerics)
 | 
						||
       ("r-genomeinfodb" ,r-genomeinfodb)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-matrix" ,r-matrix)
 | 
						||
       ("r-rcpp" ,r-rcpp)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)
 | 
						||
       ("r-summarizedexperiment" ,r-summarizedexperiment)))
 | 
						||
    (home-page "https://bioconductor.org/packages/InteractionSet")
 | 
						||
    (synopsis "Base classes for storing genomic interaction data")
 | 
						||
    (description
 | 
						||
     "This packages provides the @code{GInteractions},
 | 
						||
@code{InteractionSet} and @code{ContactMatrix} objects and associated methods
 | 
						||
for storing and manipulating genomic interaction data from Hi-C and ChIA-PET
 | 
						||
experiments.")
 | 
						||
    (license license:gpl3)))
 | 
						||
 | 
						||
(define-public r-genomicinteractions
 | 
						||
  (package
 | 
						||
    (name "r-genomicinteractions")
 | 
						||
    (version "1.14.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "GenomicInteractions" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0cnagprxj0b7p6s29iyhqwxj7hgmrh75gj52y4dlil790d1bmq2q"))))
 | 
						||
    (properties
 | 
						||
     `((upstream-name . "GenomicInteractions")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-biobase" ,r-biobase)
 | 
						||
       ("r-biocgenerics" ,r-biocgenerics)
 | 
						||
       ("r-data-table" ,r-data-table)
 | 
						||
       ("r-dplyr" ,r-dplyr)
 | 
						||
       ("r-genomeinfodb" ,r-genomeinfodb)
 | 
						||
       ("r-genomicranges" ,r-genomicranges)
 | 
						||
       ("r-ggplot2" ,r-ggplot2)
 | 
						||
       ("r-gridextra" ,r-gridextra)
 | 
						||
       ("r-gviz" ,r-gviz)
 | 
						||
       ("r-igraph" ,r-igraph)
 | 
						||
       ("r-interactionset" ,r-interactionset)
 | 
						||
       ("r-iranges" ,r-iranges)
 | 
						||
       ("r-rsamtools" ,r-rsamtools)
 | 
						||
       ("r-rtracklayer" ,r-rtracklayer)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)
 | 
						||
       ("r-stringr" ,r-stringr)))
 | 
						||
    (home-page "https://github.com/ComputationalRegulatoryGenomicsICL/GenomicInteractions/")
 | 
						||
    (synopsis "R package for handling genomic interaction data")
 | 
						||
    (description
 | 
						||
     "This R package provides tools for handling genomic interaction data,
 | 
						||
such as ChIA-PET/Hi-C, annotating genomic features with interaction
 | 
						||
information and producing various plots and statistics.")
 | 
						||
    (license license:gpl3)))
 | 
						||
 | 
						||
(define-public r-ctc
 | 
						||
  (package
 | 
						||
    (name "r-ctc")
 | 
						||
    (version "1.54.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "ctc" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0sadplm4n9n3z6inmn6y3d6qbr4hllljqh700x5fygrnfacnckk9"))))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs `(("r-amap" ,r-amap)))
 | 
						||
    (home-page "https://bioconductor.org/packages/ctc/")
 | 
						||
    (synopsis "Cluster and tree conversion")
 | 
						||
    (description
 | 
						||
     "This package provides tools for exporting and importing classification
 | 
						||
trees and clusters to other programs.")
 | 
						||
    (license license:gpl2)))
 | 
						||
 | 
						||
(define-public r-goseq
 | 
						||
  (package
 | 
						||
    (name "r-goseq")
 | 
						||
    (version "1.32.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "goseq" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0xmbb8ma32lrfy810r82y34gkspq4fqiqxykic9j4rq9rg9n9x2l"))))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-annotationdbi" ,r-annotationdbi)
 | 
						||
       ("r-biasedurn" ,r-biasedurn)
 | 
						||
       ("r-biocgenerics" ,r-biocgenerics)
 | 
						||
       ("r-genelendatabase" ,r-genelendatabase)
 | 
						||
       ("r-go-db" ,r-go-db)
 | 
						||
       ("r-mgcv" ,r-mgcv)))
 | 
						||
    (home-page "https://bioconductor.org/packages/goseq/")
 | 
						||
    (synopsis "Gene Ontology analyser for RNA-seq and other length biased data")
 | 
						||
    (description
 | 
						||
     "This package provides tools to detect Gene Ontology and/or other user
 | 
						||
defined categories which are over/under represented in RNA-seq data.")
 | 
						||
    (license license:lgpl2.0+)))
 | 
						||
 | 
						||
(define-public r-glimma
 | 
						||
  (package
 | 
						||
    (name "r-glimma")
 | 
						||
    (version "1.8.2")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "Glimma" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "0kfia60vrlys6amdchdix01iwbkwyb7nfjqn5hczsxp8rhmbg25s"))))
 | 
						||
    (properties `((upstream-name . "Glimma")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-edger" ,r-edger)
 | 
						||
       ("r-jsonlite" ,r-jsonlite)
 | 
						||
       ("r-s4vectors" ,r-s4vectors)))
 | 
						||
    (home-page "https://github.com/Shians/Glimma")
 | 
						||
    (synopsis "Interactive HTML graphics")
 | 
						||
    (description
 | 
						||
     "This package generates interactive visualisations for analysis of
 | 
						||
RNA-sequencing data using output from limma, edgeR or DESeq2 packages in an
 | 
						||
HTML page.  The interactions are built on top of the popular static
 | 
						||
representations of analysis results in order to provide additional
 | 
						||
information.")
 | 
						||
    (license license:lgpl3)))
 | 
						||
 | 
						||
(define-public r-rots
 | 
						||
  (package
 | 
						||
    (name "r-rots")
 | 
						||
    (version "1.8.0")
 | 
						||
    (source
 | 
						||
     (origin
 | 
						||
       (method url-fetch)
 | 
						||
       (uri (bioconductor-uri "ROTS" version))
 | 
						||
       (sha256
 | 
						||
        (base32
 | 
						||
         "12jvdqanyk86ihpcylp105zip22y0gkbksmyxy00q7iad0jhaqp3"))))
 | 
						||
    (properties `((upstream-name . "ROTS")))
 | 
						||
    (build-system r-build-system)
 | 
						||
    (propagated-inputs
 | 
						||
     `(("r-biobase" ,r-biobase)
 | 
						||
       ("r-rcpp" ,r-rcpp)))
 | 
						||
    (home-page "https://bioconductor.org/packages/ROTS/")
 | 
						||
    (synopsis "Reproducibility-Optimized Test Statistic")
 | 
						||
    (description
 | 
						||
     "This package provides tools for calculating the
 | 
						||
@dfn{Reproducibility-Optimized Test Statistic} (ROTS) for differential testing
 | 
						||
in omics data.")
 | 
						||
    (license license:gpl2+)))
 |